反应详情

Dissolve 373 mg (0.72 mmol) (6R)-6-{[6-(2-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid tert.-butyl ester in 4 ml 4 N hydrogen chloride in dioxan and stir for 16 h at RT. After concentrating the reaction solution by evaporation under vacuum, purify the residue by preparative RP-HPLC (gradient: water/acetonitrile). 171 mg (51% of theor.) of the desired product is obtained.

1. concentrationAfter concentrating the reaction solution
2. customby evaporation under vacuum
3. custompurify the residue by preparative RP-HPLC (gradient: water/acetonitrile)