HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-{[5-(4-Ethylphenyl)-6-(2-fluorophenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid tert.-butyl ester → HCID 58016793, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-{[5-(4-Ethylphenyl)-6-(2-fluorophenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid tert.-butyl ester | HCID 25096415 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 58016793 | HCID 58016793 | — |
Reaction Steps
Dissolve 80 mg (0.15 mmol) 6-{[5-(4-ethylphenyl)-6-(2-fluorophenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid tert.-butyl ester in 2 ml 4 N hydrogen chloride in dioxan and stir for 16 h at RT. After concentrating the reaction solution by evaporation under vacuum, purify the residue by preparative RP-HPLC (gradient: water/acetonitrile). 12 mg (16% of theor.) of the desired product is obtained as racemate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183246B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-9e70f0fcaf9b45a78b379ad71c280ad3 |
| Source note | uspto-grants-2012_05 |