反应详情

Dissolve 80 mg (0.15 mmol) 6-{[5-(4-ethylphenyl)-6-(2-fluorophenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid tert.-butyl ester in 2 ml 4 N hydrogen chloride in dioxan and stir for 16 h at RT. After concentrating the reaction solution by evaporation under vacuum, purify the residue by preparative RP-HPLC (gradient: water/acetonitrile). 12 mg (16% of theor.) of the desired product is obtained as racemate.

1. concentrationAfter concentrating the reaction solution
2. customby evaporation under vacuum
3. custompurify the residue by preparative RP-HPLC (gradient: water/acetonitrile)