反应详情

Add 1.0 ml 4 N hydrogen chloride in dioxan to 155 mg (0.29 mmol) [2-({[5-(4-ethylphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}methyl)-3,3-dimethylbutoxy]acetic acid tert.-butyl ester and stir for 48 h at RT. After concentrating the reaction solution by evaporation under vacuum, purify the residue by preparative RP-HPLC (gradient: water/acetonitrile). 122 mg (88% of theor.) of the desired product (racemate) is obtained.

1. concentrationAfter concentrating the reaction solution
2. customby evaporation under vacuum
3. custompurify the residue by preparative RP-HPLC (gradient: water/acetonitrile)