反应详情

Add 4.0 ml 4 N hydrogen chloride in dioxan to 500 mg (0.96 mmol) 3-(2-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}-1-methylpropoxy)propionic acid tert.-butyl ester and stir for 16 h at RT. After concentrating the reaction solution by evaporation under vacuum, purify the residue by preparative RP-HPLC (gradient: water/acetonitrile). 249 mg (56% of theor.) of the desired product is obtained as (R,S/S,R) racemate.

1. concentrationAfter concentrating the reaction solution
2. customby evaporation under vacuum
3. custompurify the residue by preparative RP-HPLC (gradient: water/acetonitrile)