Hydrochloric Acid → Ethyl 3-[(ethoxycarbonyl)amino]-5,6-dihydro-6,6-dimethylpyrrolo[3,4-c]pyrazole-1(4H)-carboxylate

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Reaction Steps

To a solution of 3-Ethoxycarbonylamino-6,6-dimethyl-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester (5.69 g, 14.4 mmol) in CH2Cl2 (10 mL) was added 4M HCl in 1,4-dioxane (20 mL). The solution was stirred for 1 h, at which time the volatiles were removed in vacuo to yield the desired product F1(i) as a white solid (4.8 g, 91%). Mass Spectrum: Calcd for C13H21N4O4(M+H): 297. Found: 297.

Provenance & Evidence