Hydrochloric Acid → Ethyl 3-[(ethoxycarbonyl)amino]-5,6-dihydro-6,6-dimethylpyrrolo[3,4-c]pyrazole-1(4H)-carboxylate

HRID 1927010Notes

Reaction equation

HRID 1927010 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[C:10]2[C:11]([CH3:22])([CH3:21])[N:12](C(OC(C)(C)C)=O)[CH2:13][C:9]=2[C:8]([NH:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[N:7]1)=[O:5])[CH3:2].Cl>C(Cl)Cl.O1CCOCC1>[CH2:27]([O:26][C:24]([NH:23][C:8]1[C:9]2[CH2:13][NH:12][C:11]([CH3:22])([CH3:21])[C:10]=2[N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[N:7]=1)=[O:25])[CH3:28]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59333987HCID 59333987, compound

Product 1

HCID 59333908Ethyl 3-[(ethoxycarbonyl)amino]-5,6-dihydro-6,6-dimethylpyrrolo[3,4-c]pyrazole-1(4H)-carboxylate

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 3-Ethoxycarbonylamino-6,6-dimethyl-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester (5.69 g, 14.4 mmol) in CH2Cl2 (10 mL) was added 4M HCl in 1,4-dioxane (20 mL). The solution was stirred for 1 h, at which time the volatiles were removed in vacuo to yield the desired product F1(i) as a white solid (4.8 g, 91%). Mass Spectrum: Calcd for C13H21N4O4(M+H): 297. Found: 297.

Workup

  1. customwere removed in vacuo

Sources & evidence

ORD record
ord-f43c1aa3ca214fb293723938f5b3c354
Source dataset
uspto-grants-2012_05
Patent number
US08183255B2

Reaction notes

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