Ammonia → Rufinamide

HRID 1927187Notes

Reaction equation

HRID 1927187 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[C:3]=1[CH2:4][N:5]1[CH:9]=[C:8]([C:10](OC)=[O:11])[N:7]=[N:6]1.[NH3:19]>>[CH:16]1[CH:15]=[C:14]([F:18])[C:3]([CH2:4][N:5]2[N:6]=[N:7][C:8]([C:10]([NH2:19])=[O:11])=[CH:9]2)=[C:2]([F:1])[CH:17]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22716778CGP-47292 methyl ester

Product 1

HCID 129228Rufinamide

Procedure

reacting methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate of formula IV with ammonia to obtain rufinamide of formula I.

Sources & evidence

ORD record
ord-79c7c4f2988d466e87a620446bf0b5ba
Source dataset
uspto-grants-2012_05
Patent number
US08183269B2

Reaction notes

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