反应详情

To a solution of carbon tetrachloride (20 mL) of a known compound (5-phenoxymethyl-pyridin-2-yl)-methanol (1.4 g) was added triphenylphosphine (2.1 g) at room temperature, which was heated to reflux for 6 hours and 15 minutes under a nitrogen atmosphere. The reaction mixture was cooled to room temperature, after which the solvent was evaporated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=2:1) to obtain the titled compound (1.3 g).

1. temperaturewhich was heated
2. temperatureto reflux for 6 hours and 15 minutes under a nitrogen atmosphere
3. customafter which the solvent was evaporated under a reduced pressure
4. customThe residue was purified by silica gel column chromatography (heptane:ethyl acetate=2:1)