Acetic Anhydride → HCID 135939596, compound

HRID 1927278Notes

Reaction equation

HRID 1927278 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:21]=[C:11]3[NH:12][C:13](=[O:20])[C:14]4[C:19]([N:10]3[N:9]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:5]=[CH:6][CH:7]=1.[C:22](OC(=O)C)(=[O:24])[CH3:23].C(N(CC)CC)C>C(#N)C>[O:20]=[C:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:10]2[N:9]=[C:8]([C:4]3[CH:3]=[C:2]([NH:1][C:22](=[O:24])[CH3:23])[CH:7]=[CH:6][CH:5]=3)[CH:21]=[C:11]2[NH:12]1

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 135939592HCID 135939592, compound

Product 1

HCID 135939596HCID 135939596, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of EXAMPLE 12 (0.04 g, 0.1 mmol) and acetic anhydride (0.02 mL, 1.5 mmol) in acetonitrile was treated with triethylamine (0.1 mL, 0.8 mmol). The mixture was stirred overnight at ambient temperature and filtered to provide the title compound. 1H NMR (DMSO-d6) δ 12.27 (s, 1H), 10.04 (s, 1H), 8.11-8.20 (m, 3H), 7.87-7.95 (m, 1H), 7.58-7.66 (m, 2H), 7.48-7.56 (m, 1H), 7.38 (t, J=7.8 Hz, 1H), 6.27 (s, 1H), 2.06-2.12 (m, 3H).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-5af991446a6445e6ab4f830459b82618
Source dataset
uspto-grants-2012_05
Patent number
US08183250B2

Reaction notes

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