p-Toluidine → 1-(4-Methylphenyl)aminocyclobutanenitrile

HRID 1927325노트

반응식

HRID 1927325 반응식
C[Si]([C:5]#[N:6])(C)C.[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=1.[C:15]1(=O)[CH2:18][CH2:17][CH2:16]1>ClCCl>[CH3:14][C:11]1[CH:12]=[CH:13][C:8]([NH:7][C:15]2([C:5]#[N:6])[CH2:18][CH2:17][CH2:16]2)=[CH:9][CH:10]=1

참가 물질

5

반응물 3

HCID 7813p-ToluidineHCID 14496CyclobutanoneHCID 82115Trimethylsilyl cyanide

생성물 1

HCID 609877761-(4-Methylphenyl)aminocyclobutanenitrile수율 98%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trimethylsilyl cyanide (0.93 ml, 7 mmol) was added dropwise to a mixture of p-toluidine (0.535 g, 5 mmol) and cyclobutanone (0.42 g, 6 mmol). The reaction mixture was stirred at room temperature for 6 h and then concentrated under vacuum to obtain a brown liquid which was subjected to chromatography (dichloromethane) to yield 1-(4-methylphenyl)aminocyclobutanenitrile, 7a (0.912 g, 4.9 mmol, 98%) as a yellowish solid.

후처리

  1. concentrationconcentrated under vacuum
  2. customto obtain a brown liquid which

출처 및 근거

ORD 기록
ord-ef77b67dba1946c89b67356c603864cf
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08183274B2

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