反应详情

A solution of 1.4 g (3.13 mmol, 92% pure) of methyl E-4-[3-(4-cyanobenzyl)-5-(2-hydroxyphenyl)pent-4-enyl]benzoate in 7 ml of dry acetonitrile is mixed with 1.42 g (6.26 mmol) 4-(tert-butyl)benzyl bromide and 1.30 g (9.39 mmol) of anhydrous potassium carbonate and heated under reflux for 12 hours. The mixture is then filtered and concentrated to dryness. The residue is directly purified by chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 10:1, then 1:5). 1.85 g (3.32 mmol, 93% purity, 98% of theory) of an oil are isolated.

1. temperatureheated
2. temperatureunder reflux for 12 hours
3. filtrationThe mixture is then filtered
4. concentrationconcentrated to dryness
5. customThe residue is directly purified by chromatography on silica gel (mobile phase
6. custom1.85 g (3.32 mmol, 93% purity, 98% of theory) of an oil are isolated