Oxalyl chloride → 2,2-Dimethyl-3-acetyloxypropionyl chloride
Reaction equation
[CH3:1][C:2]([CH3:11])([CH2:6][O:7][C:8](=[O:10])[CH3:9])[C:3](O)=[O:4].C(Cl)(=O)C([Cl:15])=O>C1C=CC=CC=1>[CH3:1][C:2]([CH3:11])([CH2:6][O:7][C:8](=[O:10])[CH3:9])[C:3]([Cl:15])=[O:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
The product of Step A, 2,2-dimethyl-3-acetyloxypropionic acid (11.76 g, 80 mmol) was dissolved in benzene (100 mL), and the reaction solution was cooled to 0° C., and then oxalyl chloride (15.0 g, 120 mmol) was slowly added dropwise. After 3 hours, the solvent was removed in vacuo, and the reaction mixture was distilled in vacuo to give the title compound.
Workup
- customthe solvent was removed in vacuo
- distillationthe reaction mixture was distilled in vacuo
Sources & evidence
- ORD record
- ord-0b3baacd005e4dea991e70d4ffed5fe5
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08183243B2
Reaction notes
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