HCID 86641804, compound → HCID 86641803, compound

HRID 1927573Notes

Reaction equation

HRID 1927573 reaction equation
[OH:1][C:2]1[C:12]([NH:13][C:14]2[C:17](=[O:18])[C:16](=[O:19])[C:15]=2[NH:20][C@@H:21]([CH:24]2[CH2:28][CH2:27][CH:26]([CH3:29])[O:25]2)[CH2:22][CH3:23])=[CH:11][CH:10]=[CH:9][C:3]=1[C:4]([N:6]([CH3:8])[CH3:7])=[O:5]>CC#N.O>[OH:1][C:2]1[C:12]([NH:13][C:14]2[C:17](=[O:18])[C:16](=[O:19])[C:15]=2[NH:20][C@@H:21]([C@H:24]2[CH2:28][CH2:27][C@H:26]([CH3:29])[O:25]2)[CH2:22][CH3:23])=[CH:11][CH:10]=[CH:9][C:3]=1[C:4]([N:6]([CH3:8])[CH3:7])=[O:5]

Participants

3

Reactant 1

HCID 86641804HCID 86641804, compound

Product 1

HCID 86641803HCID 86641803, compound

Reagents, catalysts & solvents 1

HCID 18373917Acetonitrile--water (1/1)Solvent

Procedure

This compound is isolated from a diastereomeric mixture of 2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-(5-methyl-tetrahydrofuran-2-yl)-propylamino]-3,4-dioxo-cyclobut-1-enylamino}-benzamide (Example 1) using reverse phase mass directed HPLC Column HICHROM HIRPB: 250×20 mm, 10 μm, eluent: 5-20% MeCN/H2O-0.1% diethylamine.

Sources & evidence

ORD record
ord-7c138e81971e4efd96ac1a1e434d4102
Source dataset
uspto-grants-2012_05
Patent number
US08183281B2

Reaction notes

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