Hydrazine → HCID 59443517, compound

HRID 1927669Notes

Reaction equation

HRID 1927669 reaction equation
[NH2:1][NH2:2].[CH3:3][N:4]([CH3:25])[S:5]([N:8]1[CH:12]=[C:11]([CH2:13][C:14]([CH3:18])([CH3:17])[CH2:15][CH3:16])[N:10]=[C:9]1[CH2:19][CH2:20][C:21](OC)=[O:22])(=[O:7])=[O:6]>CO>[CH3:17][C:14]([CH3:18])([CH2:15][CH3:16])[CH2:13][C:11]1[N:10]=[C:9]([CH2:19][CH2:20][C:21]([NH:1][NH2:2])=[O:22])[N:8]([S:5]([N:4]([CH3:25])[CH3:3])(=[O:7])=[O:6])[CH:12]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 68672466HCID 68672466, compound

Product 1

HCID 59443517HCID 59443517, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrazine (0.45 mL, 14.5 mmol) was added to a solution of methyl 3-[1-[(dimethyl-amino)sulfonyl]-4-(2,2-dimethylbutyl)-1H-imidazol-2-yl]propanoate (1 g, 2.9 mmol) in dry methanol (2 mL). After stirring at rt for 3 hr, volatiles were removed in vacuo, and chromatography of the resulting residue over silica eluting with 0-40% ethyl acetate/hexane afforded the title compound.

Workup

  1. customvolatiles were removed in vacuo, and chromatography of the resulting residue over silica eluting with 0-40% ethyl acetate/hexane

Sources & evidence

ORD record
ord-6f82e4d68f254403a713055f03ccbe81
Source dataset
uspto-grants-2012_05
Patent number
US08183275B2

Reaction notes

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