Sodium Sulfite → HCID 178506558, compound

HRID 1927684Notes

Reaction equation

HRID 1927684 reaction equation
[I:1][C:2]1[N:3]=[C:4]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[CH:12][CH:11]=2)[NH:5][C:6]=1I.S([O-])([O-])=O.[Na+].[Na+]>C(O)C.O>[I:1][C:2]1[N:3]=[C:4]([CH2:8][CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[CH:14][CH:15]=2)[NH:5][CH:6]=1

Participants

5

Reactant 2

HCID 24437Sodium SulfiteHCID 686726842-[4-[2-(4,5-diiodo-1H-imidazol-2-yl)ethyl]phenyl]pyridine

Product 1

HCID 178506558HCID 178506558, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 2-{4-[2-(4,5-diiodo-1H-imidazol-2-yl)ethyl]phenyl}pyridine (11.2 g, 22.4 mmol) and sodium sulfite (3.1 g, 24.7 mmol) in ethanol (200 mL) and water (200 mL) was heated at 100° C. for 2 days. The reaction mixture was concentrated to half its original volume and partitioned between ethyl acetate and water. The organic phase was separated and concentrated in vacuo to afford 2-{4-[2-(4-iodo-1H-imidazol-2-yl)ethyl]phenyl}pyridine, which was used without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated to half its original volume
  2. custompartitioned between ethyl acetate and water
  3. customThe organic phase was separated
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-7e1f3486b3574dbf93eccbfcd40d8f67
Source dataset
uspto-grants-2012_05
Patent number
US08183275B2

Reaction notes

Loading…