HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2,3-Dihydro-1H-isoindol-5-ol--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl 5-hydroxy-2,3-dihydro-1H-isoindole-2-carboxylate | HCID 18630963 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2,3-Dihydro-1H-isoindol-5-ol--hydrogen chloride (1/1) | HCID 44474400 | — |
Reaction Steps
2 g (235.3 mmol) of tert-butyl 5-hydroxy-1,3-dihydroisoindole-2-carboxylate are dissolved in 20 ml of a 4 M hydrogen chloride solution in dioxane. After 1 h at 22° C., the mixture is evaporated to dryness in vacuo. The resultant white crystals (1.4 g (96%) MW 171.6) are employed in the following reactions without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183279B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-db4b9eefd42a4c47a3ca5625b5336577 |
| Source note | uspto-grants-2012_05 |