反应详情

2 g (235.3 mmol) of tert-butyl 5-hydroxy-1,3-dihydroisoindole-2-carboxylate are dissolved in 20 ml of a 4 M hydrogen chloride solution in dioxane. After 1 h at 22° C., the mixture is evaporated to dryness in vacuo. The resultant white crystals (1.4 g (96%) MW 171.6) are employed in the following reactions without further purification.

1. customthe mixture is evaporated to dryness in vacuo
2. customThe resultant white crystals (1.4 g (96%) MW 171.6) are employed in the following reactions without further purification