Hydrochloric Acid → HCID 68469006, compound

HRID 1927713Notes

Reaction equation

HRID 1927713 reaction equation
C(OC([NH:8][CH2:9][C:10]1[CH:11]=[C:12]([CH2:34][C:35]([O:37][CH3:38])=[O:36])[CH:13]=[CH:14][C:15]=1[O:16][C:17]1[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:33])[C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[C:27]([Cl:32])[CH:26]=2)=[CH:19][CH:18]=1)=O)(C)(C)C.Cl>>[NH2:8][CH2:9][C:10]1[CH:11]=[C:12]([CH2:34][C:35]([O:37][CH3:38])=[O:36])[CH:13]=[CH:14][C:15]=1[O:16][C:17]1[CH:18]=[CH:19][C:20]([NH:23][C:24](=[O:33])[C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[C:27]([Cl:32])[CH:26]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68466753HCID 68466753, compound

Product 1

HCID 68469006HCID 68469006, compoundYield 93.8%

Procedure

Methyl 2-(3-((tert-butoxycarbonyl)aminomethyl)-4-(4-(3,4-dichlorobenzamido)phenoxy)phenyl)acetate (130 mg, 0.232 mmol) was treated with HCl (0.581 mL, 2.32 mmol), After stirring for 3 hours, the material was concentrated to yield 100 mg of methyl 2-(3-(aminomethyl)-4-(4-(3,4-dichlorobenzamido)phenoxy)phenyl)acetate.

Workup

  1. concentrationthe material was concentrated

Sources & evidence

ORD record
ord-30a2f5484f114a5aa1de767bd76901e0
Source dataset
uspto-grants-2012_05
Patent number
US08183289B2

Reaction notes

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