1,4-Dioxane hydrochloride → (2S)-Piperidine-2-carboxamide hydrochloride

HRID 1927803Notes

Reaction equation

HRID 1927803 reaction equation
C(OC([NH:8][C:9]([C@@H:11]1[CH2:16][CH2:15][CH2:14][CH2:13][NH:12]1)=[O:10])=O)(C)(C)C.[ClH:17].O1CCOCC1>>[ClH:17].[NH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][C@H:11]1[C:9]([NH2:8])=[O:10]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 51534906(2S)-N-(tert-Butyloxycarbonyl)piperidine-2-carboxamide

Product 1

HCID 22818427(2S)-Piperidine-2-carboxamide hydrochlorideYield 89%

Procedure

(2S)—N-(tert-Butyloxycarbonyl)piperidine-2-carboxamide (1.7 g, 7.4 mmol) was dissolved in 4M HCl/dioxan (50 ml). After 1 h at room temperature the solvent was evaporated in vacuo to give a white solid identified as the title compound (1.1 g, 6.7 mmol, 89%).

Workup

  1. customAfter 1 h at room temperature the solvent was evaporated in vacuo
  2. customto give a white solid

Sources & evidence

ORD record
ord-b4955052a15144bea558c060ccd0b5dd
Source dataset
uspto-grants-2012_05
Patent number
US08183280B2

Reaction notes

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