HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → (2S)-Piperidine-2-carboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | (2S)-N-(tert-Butyloxycarbonyl)piperidine-2-carboxamide | HCID 51534906 | — |
| Product | (2S)-Piperidine-2-carboxamide hydrochloride | HCID 22818427 | 89% |
Reaction Steps
(2S)—N-(tert-Butyloxycarbonyl)piperidine-2-carboxamide (1.7 g, 7.4 mmol) was dissolved in 4M HCl/dioxan (50 ml). After 1 h at room temperature the solvent was evaporated in vacuo to give a white solid identified as the title compound (1.1 g, 6.7 mmol, 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183280B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-b4955052a15144bea558c060ccd0b5dd |
| Source note | uspto-grants-2012_05 |