Phosphorus oxychloride → 2-Chloro-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)pyridine

HRID 1927837Notes

Reaction equation

HRID 1927837 reaction equation
[CH:1]1([C:4]2[NH:9][C:8](=O)[CH:7]=[C:6]([C:11]3[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=3)[CH:5]=2)[CH2:3][CH2:2]1.P(Cl)(Cl)([Cl:23])=O>>[Cl:23][C:8]1[CH:7]=[C:6]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[CH:5]=[C:4]([CH:1]2[CH2:3][CH2:2]2)[N:9]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 574686496-Cyclopropyl-4-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one

Product 1

HCID 574686482-Chloro-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)pyridine

Procedure

The title compound was prepared from 6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one (5.0 g, 18 mmol) and phosphoryl chloride (8.2 mL, 90 mmol) according to the general procedure Ia to d preparation of chlorides. Obtained as an off-white solid (4.73 g, 88%). MS (ISP) 298.2 [(M+H)+] and 300 [(M+2+H)+].

Sources & evidence

ORD record
ord-cf760fbde0c24375b7983c79b4452b7e
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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