Phosphorus oxychloride → 2-Chloro-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine

HRID 1927845Notes

Reaction equation

HRID 1927845 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[NH:12][C:11](=O)[N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].O=P(Cl)(Cl)[Cl:22]>>[Cl:22][C:11]1[N:10]=[C:9]([C:4]2[CH:5]=[CH:6][C:7]([F:8])=[C:2]([F:1])[CH:3]=2)[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:12]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 574686694-(3,4-Difluoro-phenyl)-6-trifluoromethyl-1h-pyrimidin-2-one

Product 1

HCID 574686682-Chloro-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine

Procedure

The title compound was prepared from 4-(3,4-difluoro-phenyl)-6-trifluoromethyl-1H-pyrimidin-2-one (14.7 g, 0.053 mol) and phosphoroxychloride (148 mL) according to the general procedure I. Obtained as a light brown solid (15.6 g, 99%). MS (EI) 294.0 [(M)+]; mp 53° C.

Sources & evidence

ORD record
ord-44052153c26446e0b9b25f8d3b68ba6a
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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