Phosphorus oxybromide → HCID 57468681, compound

HRID 1927850Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[NH:5][C:4](=O)[CH:3]=1.P(Br)(Br)([Br:21])=O>>[Br:21][C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:5]=1

Participants

Reactant 2

HCID 24613Phosphorus oxybromide

HCID 57468629HCID 57468629, compound

Product 1

HCID 57468681HCID 57468681, compound

Procedure

The title compound was prepared from 4-methyl-6-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one (example A.23 step 1) (25.32 g, 100 mmol) and phosphoryl bromide (86.0 g, 300 mmol) according to the general procedure Ia to d preparation of bromides. Obtained as a light yellow solid (29.27 g, 93%). MS (ISP) 316.0 [(M+H)+] and 318.0 [(M+2+H)+].

Sources & evidence

ORD record: ord-3b5c6fec850b4735bffb2cd06d964dcd
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08183262B2

Reaction notes

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