2-Chloro-4-(4-chlorophenyl)-6-cyclopropylpyrimidine → 2-(4-Bromo-imidazol-1-yl)-4-(4-chloro-phenyl)-6-cyclopropyl-pyrimidine

HRID 1927874Notes

Reaction equation

HRID 1927874 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:5]=[C:4]([CH:15]2[CH2:17][CH2:16]2)[N:3]=1.[Br:18][C:19]1[N:20]=[CH:21][NH:22][CH:23]=1>>[Br:18][C:19]1[N:20]=[CH:21][N:22]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=3)[CH:5]=[C:4]([CH:15]3[CH2:17][CH2:16]3)[N:3]=2)[CH:23]=1

Participants

3

Reactant 2

HCID 574686162-Chloro-4-(4-chlorophenyl)-6-cyclopropylpyrimidineHCID 178418934HCID 178418934, compound

Product 1

HCID 574687382-(4-Bromo-imidazol-1-yl)-4-(4-chloro-phenyl)-6-cyclopropyl-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-(4-chloro-phenyl)-6-cyclopropyl-pyrimidine (example A.13) (0.80 g, 3.0 mmol) and commercially available 4-bromo-imidazole (0.66 g, 4.50 mmol) according to the general procedure IVa. Obtained as a white solid (0.71 g, 63%). MS (ISP) 375.1 [(M+H)+].

Sources & evidence

ORD record
ord-1bf3681f19a84534b1ff67eb5e6a944e
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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