2-Chloro-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)pyridine → 2-Cyclopropyl-6-(4-iodo-imidazol-1-yl)-4-(4-trifluoromethyl-phenyl)-pyridine

HRID 1927877Notes

Reaction equation

HRID 1927877 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[CH:5]=[C:4]([CH:18]2[CH2:20][CH2:19]2)[N:3]=1.[I:21][C:22]1[N:23]=[CH:24][NH:25][CH:26]=1>>[CH:18]1([C:4]2[CH:5]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=3)[CH:7]=[C:2]([N:25]3[CH:26]=[C:22]([I:21])[N:23]=[CH:24]3)[N:3]=2)[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 574686482-Chloro-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)pyridineHCID 178506559HCID 178506559, compound

Product 1

HCID 574687412-Cyclopropyl-6-(4-iodo-imidazol-1-yl)-4-(4-trifluoromethyl-phenyl)-pyridine

Procedure

The title compound was prepared 2-chloro-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridine (example A.33) (1.0 g, 3 mmol) and commercially available 4-iodo-imidazole (0.782 g, 4 mmol) according to the general procedure IVa. Obtained as a yellow solid (1.44 g, 93%). MS (ISP) 456.2 [(M+H)+].

Sources & evidence

ORD record
ord-f3357b2e79b84416aceab33790a6b3c9
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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