HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)pyridine → 2-Cyclopropyl-6-(4-iodo-imidazol-1-yl)-4-(4-trifluoromethyl-phenyl)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)pyridine | HCID 57468648 | — |
| Reactant | HCID 178506559 | HCID 178506559 | — |
| Product | 2-Cyclopropyl-6-(4-iodo-imidazol-1-yl)-4-(4-trifluoromethyl-phenyl)-pyridine | HCID 57468741 | — |
Reaction Steps
The title compound was prepared 2-chloro-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridine (example A.33) (1.0 g, 3 mmol) and commercially available 4-iodo-imidazole (0.782 g, 4 mmol) according to the general procedure IVa. Obtained as a yellow solid (1.44 g, 93%). MS (ISP) 456.2 [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183262B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-f3357b2e79b84416aceab33790a6b3c9 |
| Source note | uspto-grants-2012_05 |