2-Chloro-4-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidine → 2-(4-Bromo-imidazol-1-yl)-4-(3,4-dichlorophenyl)-6-trifluoromethyl-pyrimidine

HRID 1927897Notes

Reaction equation

HRID 1927897 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[CH:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[N:3]=1.[Br:20][C:21]1[N:22]=[CH:23][NH:24][CH:25]=1>>[Br:20][C:21]1[N:22]=[CH:23][N:24]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=3)[CH:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[N:3]=2)[CH:25]=1

Participants

3

Reactant 2

HCID 154777402-Chloro-4-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidineHCID 178418934HCID 178418934, compound

Product 1

HCID 574687572-(4-Bromo-imidazol-1-yl)-4-(3,4-dichlorophenyl)-6-trifluoromethyl-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-(3,4-dichloro-phenyl)-6-trifluoromethyl-pyrimidine (example A.7) (0.50 g, 1.53 mmol) and commercially available 4-bromo-imidazole (0.34 g, 2.31 mmol) according to the general procedure IVb. Obtained as a white solid (0.38 g, 57%). MS (ISP) 439.0 [(M+H)+]; mp 225.5° C.

Sources & evidence

ORD record
ord-6ca423567b7644b4a8163960532b30fb
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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