HCID 57468657, Verbindung → 2-(4-Bromo-imidazol-1-yl)-4-methyl-6-(3-methyl-4-trifluoromethyl-phenyl)-pyrimidine

HRID 1927906Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1927906
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[C:10]([CH3:18])[CH:9]=2)[CH:5]=[C:4]([CH3:19])[N:3]=1.[Br:20][C:21]1[N:22]=[CH:23][NH:24][CH:25]=1>>[Br:20][C:21]1[N:22]=[CH:23][N:24]([C:2]2[N:3]=[C:4]([CH3:19])[CH:5]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[C:10]([CH3:18])[CH:9]=3)[N:7]=2)[CH:25]=1

Komponenten

3

Edukt 2

HCID 57468657HCID 57468657, VerbindungHCID 178418934HCID 178418934, Verbindung

Produkt 1

HCID 574687682-(4-Bromo-imidazol-1-yl)-4-methyl-6-(3-methyl-4-trifluoromethyl-phenyl)-pyrimidine

Versuchsvorschrift

The title compound was prepared from 2-chloro-4-(3-methyl-4-trifluoromethyl-phenyl)-6-methyl-pyrimidine (example A.40) (0.40 g, 1.4 mmol) and commercially available 4-bromo-imidazole (0.31 g, 2.1 mmol) according to the general procedure IVa. Obtained as a light brown solid (0.54 g, 97%). MS (ISP) 399.0 [(M+H)+]; mp 157.5° C.

Quellen und Nachweise

ORD-Eintrag
ord-1174c47406a243f08f863a81bae99290
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08183262B2

Notizen zur Reaktion

Wird geladen…