HCID 60209325, compound → HCID 60209336, compound

HRID 1927909Notes

Reaction equation

HRID 1927909 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[C:10]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])[CH:9]=2)[CH:5]=[C:4]([C:24]([F:27])([F:26])[F:25])[N:3]=1.[Br:28][C:29]1[N:30]=[CH:31][NH:32][CH:33]=1>>[Br:28][C:29]1[N:30]=[CH:31][N:32]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:16])([F:17])[F:15])=[C:10]([O:18][CH2:19][C:20]([F:21])([F:22])[F:23])[CH:9]=3)[CH:5]=[C:4]([C:24]([F:27])([F:25])[F:26])[N:3]=2)[CH:33]=1

Participants

3

Reactant 2

HCID 60209325HCID 60209325, compoundHCID 178418934HCID 178418934, compound

Product 1

HCID 60209336HCID 60209336, compound

Procedure

The title compound was prepared from 2-chloro-4-[3-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-6-trifluoromethyl-pyrimidine (example A.39) (0.85 g, 2.0 mmol) and commercially available 4-bromo-imidazole (0.44 g, 3.0 mmol) according to the general procedure IVa. Obtained as a light yellow solid (0.83 g, 78%). MS (ISP) 535.0 [(M+H)+]; mp 159° C.

Sources & evidence

ORD record
ord-1863ef9d64904903b8196c92a001f702
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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