HCID 57468659, compound → 2-(4-Bromo-imidazol-1-yl)-4-(3,4-dichlorophenyl)-6-methyl-pyrimidine

HRID 1927916Notes

Reaction equation

HRID 1927916 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[CH:5]=[C:4]([CH3:16])[N:3]=1.[Br:17][C:18]1[N:19]=[CH:20][NH:21][CH:22]=1>>[Br:17][C:18]1[N:19]=[CH:20][N:21]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=3)[CH:5]=[C:4]([CH3:16])[N:3]=2)[CH:22]=1

Participants

3

Reactant 2

HCID 57468659HCID 57468659, compoundHCID 178418934HCID 178418934, compound

Product 1

HCID 574687752-(4-Bromo-imidazol-1-yl)-4-(3,4-dichlorophenyl)-6-methyl-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-(3,4-dichloro-phenyl)-6-methyl-pyrimidine (example A.41) (0.4 g, 1.46 mmol) and commercially available 4-bromo-imidazole (0.32 g, 2.18 mmol) according to the general procedure IVa. Obtained as a light brown solid (0.33 g, 59%). MS (ISP) 385.0 [(M+H)+]; mp 219.5° C.

Sources & evidence

ORD record
ord-598f1434c62a41dba62ab5705ad39e58
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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