HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine → 2-(4-Iodo-imidazol-1-yl)-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine | HCID 57468599 | — |
| Reactant | HCID 178506559 | HCID 178506559 | — |
| Product | 2-(4-Iodo-imidazol-1-yl)-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine | HCID 57468782 | — |
Reaction Steps
The title compound was prepared from 2-chloro-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine (example A.2) (1.31 g, 4.0 mmol) and commercially available 4-iodo-imidazole (0.85 g, 4.4 mmol) according to the general procedure IVa. Obtained as a pink solid (1.88 g, 97%). MS (ISP) 485.3 [(M+H)+]; mp 194° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183262B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-bc4aaedafad442bdafed5e55f2b98ca3 |
| Source note | uspto-grants-2012_05 |