2,4-Dibromo-1,3-thiazole → 2-(4-Bromo-thiazol-2-yl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine

HRID 1927935Notes

Reaction equation

HRID 1927935 reaction equation
I[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[CH:5]=[C:4]([CH3:18])[N:3]=1.Br[C:20]1[S:21][CH:22]=[C:23]([Br:25])[N:24]=1>>[Br:25][C:23]1[N:24]=[C:20]([C:2]2[CH:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=3)[CH:5]=[C:4]([CH3:18])[N:3]=2)[S:21][CH:22]=1

Participants

3

Reactant 2

HCID 27632972,4-Dibromo-1,3-thiazoleHCID 574686452-Iodo-6-methyl-4-(4-trifluoromethyl-phenyl)pyridine

Product 1

HCID 574687942-(4-Bromo-thiazol-2-yl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine

Procedure

The title compound was prepared from 2-iodo-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine (example A.31) (4.0 g, 9.36 mmol) and commercially available 2,4-dibromo-thiazole (2.53 g, 10.41 mmol) according to the general procedure IVc protocol b. Obtained as a light yellow solid (1.22 g, 31%). MS (ISP) 399.1 [(M+H)+] and 401.1 [(M+2+H)+].

Sources & evidence

ORD record
ord-5ea1930d1f3a4bacb278cb59186e3257
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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