HCID 57468674, compound → HCID 57468798, compound

HRID 1927939Notes

Reaction equation

HRID 1927939 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[CH:5]=[C:4]([CH3:16])[N:3]=1.[I:17][C:18]1[N:19]=[CH:20][NH:21][CH:22]=1>>[Cl:15][C:10]1[CH:9]=[C:8]([C:6]2[CH:5]=[C:4]([CH3:16])[N:3]=[C:2]([N:21]3[CH:22]=[C:18]([I:17])[N:19]=[CH:20]3)[CH:7]=2)[CH:13]=[CH:12][C:11]=1[Cl:14]

Participants

3

Reactant 2

HCID 57468674HCID 57468674, compoundHCID 178506559HCID 178506559, compound

Product 1

HCID 57468798HCID 57468798, compound

Procedure

The title compound was prepared from 2-chloro-4-(3,4-dichloro-phenyl)-6-methyl-pyridine (example A.51) (3.5 g, 12.8 mmol) and commercially available 4-iodo-imidazole (2.99 g, 15.4 mmol) according to the general procedure IVa. Obtained as a light grey solid (0.90 g, 16%). MS (ISP) 430.0 [(M+H)+], 432.1 [(M+2+H)+] and 434.0 [(M+4+H)+].

Sources & evidence

ORD record
ord-259e4c3a31ad46959ab4e60a4c26303e
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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