2-Chloro-6-trifluoromethyl-4-(4-trifluoromethylphenyl)-pyridine → 2-(4-Iodo-imidazol-1-yl)-6-trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine

HRID 1927947Notes

Reaction equation

HRID 1927947 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[CH:5]=[C:4]([C:18]([F:21])([F:20])[F:19])[N:3]=1.[I:22][C:23]1[N:24]=[CH:25][NH:26][CH:27]=1>>[I:22][C:23]1[N:24]=[CH:25][N:26]([C:2]2[CH:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=3)[CH:5]=[C:4]([C:18]([F:21])([F:20])[F:19])[N:3]=2)[CH:27]=1

Participants

3

Reactant 2

HCID 574686352-Chloro-6-trifluoromethyl-4-(4-trifluoromethylphenyl)-pyridineHCID 178506559HCID 178506559, compound

Product 1

HCID 574688062-(4-Iodo-imidazol-1-yl)-6-trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine

Procedure

The title compound was prepared from 2-chloro-6-trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine (example A.26) (2.0 g, 6.14 mmol) and commercially available 4-iodo-imidazole (1.31 g, 6.75 mmol) according to the general procedure IVa. Obtained as a white solid (1.90 g, 82%). MS (ISP) 484.1 [(M+H)+].

Sources & evidence

ORD record
ord-4ed03d6661bb46fcb772c7d09d42d690
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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