3-Sulfamoylbenzoic acid → HCID 57468846, compound

HRID 1927992Notes

Reaction equation

HRID 1927992 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]=[C:10]([C:18]([NH:20][OH:21])=[NH:19])[N:9]=2)=[CH:4][CH:3]=1.[S:22]([C:26]1[CH:27]=[C:28]([CH:32]=[CH:33][CH:34]=1)[C:29](O)=O)(=[O:25])(=[O:24])[NH2:23]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:15])([F:16])[F:17])[N:11]=[C:10]([C:18]3[N:19]=[C:29]([C:28]4[CH:27]=[C:26]([S:22]([NH2:23])(=[O:25])=[O:24])[CH:34]=[CH:33][CH:32]=4)[O:21][N:20]=3)[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2293523-Sulfamoylbenzoic acidHCID 178513397HCID 178513397, compound

Product 1

HCID 57468846HCID 57468846, compound

Procedure

The title compound was prepared from 4-(4-chloro-phenyl)-N-hydroxy-6-trifluoromethyl-pyrimidine-2-carboxamidine (example C.1) (0.16 g, 0.5 mmol) and commercially available 3-sulfamoyl-benzoic acid (0.1 g, 0.5 mmol) according to the general procedure VI. Obtained as a white solid (0.1 g, 43%). MS (ISP) 482.1 [(M+H)+]; mp 273° C.

Sources & evidence

ORD record
ord-bf7193f8117d4b369b29e8692dbda490
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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