2-Iodo-6-methyl-4-(4-trifluoromethyl-phenyl)pyridine → 2-Methyl-6-[3-(4-methyl-imidazol-1-yl)-phenyl]-4-(4-trifluoromethyl-phenyl)-pyridine

HRID 1928253Notes

Reaction equation

HRID 1928253 reaction equation
I[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[CH:5]=[C:4]([CH3:18])[N:3]=1.[CH3:19][C:20]1[N:21]=[CH:22][N:23]([C:25]2[CH:30]=[CH:29][CH:28]=[C:27](B3OC(C)(C)C(C)(C)O3)[CH:26]=2)[CH:24]=1>>[CH3:18][C:4]1[CH:5]=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([C:14]([F:16])([F:15])[F:17])=[CH:12][CH:13]=2)[CH:7]=[C:2]([C:27]2[CH:28]=[CH:29][CH:30]=[C:25]([N:23]3[CH:24]=[C:20]([CH3:19])[N:21]=[CH:22]3)[CH:26]=2)[N:3]=1

Participants

3

Reactant 2

HCID 574686452-Iodo-6-methyl-4-(4-trifluoromethyl-phenyl)pyridineHCID 574690003-(4-Methylimidazol-1-yl)phenylboronic acid pinacol ester

Product 1

HCID 574689992-Methyl-6-[3-(4-methyl-imidazol-1-yl)-phenyl]-4-(4-trifluoromethyl-phenyl)-pyridine

Procedure

The title compound was prepared from 2-iodo-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine (example A.31) (400 mg, 1.09 mmol) and 4-methyl-1-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazole [in situ prepared by the following sequence:

Workup

  1. customprepared by the following sequence

Sources & evidence

ORD record
ord-90de65a9fc6245dc8135938e53b6d521
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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