HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Iodo-6-methyl-4-(4-trifluoromethyl-phenyl)pyridine → 2-Methyl-6-[3-(4-methyl-imidazol-1-yl)-phenyl]-4-(4-trifluoromethyl-phenyl)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Iodo-6-methyl-4-(4-trifluoromethyl-phenyl)pyridine | HCID 57468645 | — |
| Reactant | 3-(4-Methylimidazol-1-yl)phenylboronic acid pinacol ester | HCID 57469000 | — |
| Product | 2-Methyl-6-[3-(4-methyl-imidazol-1-yl)-phenyl]-4-(4-trifluoromethyl-phenyl)-pyridine | HCID 57468999 | — |
Reaction Steps
The title compound was prepared from 2-iodo-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine (example A.31) (400 mg, 1.09 mmol) and 4-methyl-1-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazole [in situ prepared by the following sequence:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183262B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-90de65a9fc6245dc8135938e53b6d521 |
| Source note | uspto-grants-2012_05 |