反应详情

温度

50 °C

To the above prepared N-tert-butyl-3-{4-[4-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-pyrimidin-2-yl}-benzenesulfonamide (0.110 g, 0.19 mmol) was added TFA (6 mL) and the reaction mixture was stirred at 50° C. for 2 h. The mixture was evaporated to dryness and partitioned between EtOAc and saturated NaHCO3 solution, the organic layer was dried over Na2SO4. Removal of the solvent in vacuum left a crude product which was triturated with diethyl ether to give the title compound as a white solid (0.235 g, 100%). MS (ISP) 471.2 [(M+H)+]; mp>250° C.

1. customThe mixture was evaporated to dryness
2. custompartitioned between EtOAc and saturated NaHCO3 solution
3. dry with materialthe organic layer was dried over Na2SO4
4. customRemoval of the solvent in vacuum
5. waitleft a crude product which
6. customwas triturated with diethyl ether