反应详情

温度

23 °C

To 2-{1-[6-trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid tert-butylamide (example 302) (0.150 g, 0.260 mmol) was added TFA (5 mL) and the reaction mixture was stirred at 23° C. for 16 h. The mixture was evaporated to dryness and partitioned between TBME and saturated NaHCO3 solution, the organic layer was dried over Na2SO4. Removal of the solvent in vacuum left a crude product which was triturated with diethyl ether to give the title compound as a white solid (0.120 g, 88%). MS (ISP) 520.2 [(M+H)+]; mp>250° C.

1. customThe mixture was evaporated to dryness
2. custompartitioned between TBME and saturated NaHCO3 solution
3. dry with materialthe organic layer was dried over Na2SO4
4. customRemoval of the solvent in vacuum
5. waitleft a crude product which
6. customwas triturated with diethyl ether