(R)-3-phenyllactic acid → HCID 66933229, 화합물

HRID 1928576노트

반응식

HRID 1928576 반응식
[NH2:1][CH:2]1[C:13]2[CH:5]([N:6]=[C:7]3[C:12]=2[CH:11]=[CH:10][CH:9]=[CH:8]3)[CH2:4][CH2:3]1.O[C@H](CC1C=CC=CC=1)C(O)=O>>[NH2:1][C@@H:2]1[C:13]2[CH:5]([N:6]=[C:7]3[C:12]=2[CH:11]=[CH:10][CH:9]=[CH:8]3)[CH2:4][CH2:3]1

참가 물질

3

반응물 2

HCID 643327(R)-3-phenyllactic acidHCID 66933239Aminotetrahydrocyclopenta[b]indole

생성물 1

HCID 66933229HCID 66933229, 화합물

실험 절차

In Step B, the racemic aminotetrahydrocyclopenta[b]indole of formula (3) is resolved using (R)-2-hydroxy-3-phenylpropionic acid to obtain the salt of the (S)-aminotetrahydrocyclopenta[b]indole of formula (8). The salt formation is preferably done in isopropanol, with heating for about 1 to 6 hours, followed by cooling to obtain the desired enantiomer.

출처 및 근거

ORD 기록
ord-ccd5a068eccb479e833b05dadd499c71
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08183388B2

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