反应详情

In Step B, the racemic aminotetrahydrocyclopenta[b]indole of formula (3) is resolved using (R)-2-hydroxy-3-phenylpropionic acid to obtain the salt of the (S)-aminotetrahydrocyclopenta[b]indole of formula (8). The salt formation is preferably done in isopropanol, with heating for about 1 to 6 hours, followed by cooling to obtain the desired enantiomer.