Sodium borohydride → (1-(1-(5-Ethylpyrimidin-2-yl)piperidin-4-yl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanol
Reaction equation
[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([N:9]2[CH2:14][CH2:13][CH:12]([N:15]3[C:19]([C:20]([F:23])([F:22])[F:21])=[C:18]([C:24](OCC)=[O:25])[CH:17]=[N:16]3)[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2].[BH4-].[Na+]>>[CH2:1]([C:3]1[CH:8]=[N:7][C:6]([N:9]2[CH2:14][CH2:13][CH:12]([N:15]3[C:19]([C:20]([F:23])([F:22])[F:21])=[C:18]([CH2:24][OH:25])[CH:17]=[N:16]3)[CH2:11][CH2:10]2)=[N:5][CH:4]=1)[CH3:2]Participants
3
Procedure
The title compound was synthesized using ethyl 1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate and sodium borohydride in a manner similar to that described in Example 66, Step 2.
Sources & evidence
- ORD record
- ord-ddc3b1996ad145f2aed1d1f54e70c5af
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08183381B2
Reaction notes
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