Allyl chloroformate → HCID 25175256, compound

HRID 1928633Notes

Reaction equation

HRID 1928633 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([N:8]2[N:12]=[C:11]([CH2:13][O:14][C:15]3[CH:16]=[CH:17][C:18]([N:21]4[CH:25]=[N:24][N:23]=[N:22]4)=[N:19][CH:20]=3)[CH:10]=[N:9]2)[CH2:4][CH2:3]1.Cl[C:27]([O:29][CH2:30][CH:31]=[CH2:32])=[O:28]>>[N:21]1([C:18]2[N:19]=[CH:20][C:15]([O:14][CH2:13][C:11]3[CH:10]=[N:9][N:8]([CH:5]4[CH2:4][CH2:3][N:2]([C:27]([O:29][CH2:30][CH:31]=[CH2:32])=[O:28])[CH2:7][CH2:6]4)[N:12]=3)=[CH:16][CH:17]=2)[CH:25]=[N:24][N:23]=[N:22]1

Participants

3

Reactant 2

HCID 18052Allyl chloroformateHCID 687466245-((2-(piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine hydrochloride

Product 1

HCID 25175256HCID 25175256, compound

Procedure

The title compound was synthesized from Intermediate 15 and allyl chloroformate in a manner similar to that described in Journal of Medicinal Chemistry 1998, 41, 4983-4994. 1H NMR (CDCl3): δ 9.46 (1H, s), 8.28 (1H, m), 8.04 (1H, m), 7.73 (1H, s), 7.61 (1H, m), 5.95 (1H, m), 5.40-5.20 (4H, m), 4.64 (3H, m), 4.24 (2H, m), 3.10 (2H, m), 2.16 (4H, m).

Sources & evidence

ORD record
ord-155e6fcd58bd4ffd8c141cddd730e6e2
Source dataset
uspto-grants-2012_05
Patent number
US08183381B2

Reaction notes

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