反应详情

温度

90 °C

A mixture of 4,4′-dibromobiphenyl (8.46 g=27.4 mmol), Pd(OAc)2 (105 mg=0.18 mmol), dppf (253 mg=0.46 mmol), N-(1-naphthyl)aniline (2.0 g=9.13 mmol) and sodium t-butoxide (1.32 g=13.7 mmol) in dry toluene was placed in a three-necked flask under a nitrogen atmosphere and stirred at 90° C. for 15 h. After cooling, the reaction was quenched by adding water and then extracted by ethyl acetate. The organic layer was dried over anhydrous MgSO4 and evaporated under vacuum. The products were purified by a silica gel column eluted with hexane. White solid of compound 2N was obtained in 70% yield (2.86 g=6.37 mmol).

1. customwas placed in a three-necked flask under a nitrogen atmosphere
2. temperatureAfter cooling
3. customthe reaction was quenched
4. additionby adding water
5. extractionextracted by ethyl acetate
6. dry with materialThe organic layer was dried over anhydrous MgSO4
7. customevaporated under vacuum
8. customThe products were purified by a silica gel column
9. washeluted with hexane