反应详情

温度

60 °C

(R)—N2-Indan-1-yl-quinoline-2,6-diamine (0.30 g, 1.09 mmol) was dissolved in toluene (5 mL). Isopropyl isocyanate (0.93 g, 1.09 mmol) was added and the reaction mixture was stirred at 60° C. for 2 h. Upon cooling to room temperature a precipitation formed which was filtered off and washed twice with dichloromethane. After drying the title compound was obtained as a white solid (330 mg, 85%); MS: m/e=276.4 (M+H+).

1. temperatureUpon cooling to room temperature
2. customa precipitation
3. customformed which
4. filtrationwas filtered off
5. washwashed twice with dichloromethane
6. dry with materialAfter drying the title compound