反应详情

(R)—N2-indan-1-yl-quinoline-2,6-diamine (100 mg, 0.36 mmol) and potassium isocyanate (32 mg, 0.40 mmol) were stirred in a 1:1 mixture of water and acetic acid (3 mL) at ambient temperature for 2 h. Then a satured solution of sodium bicarbonate was added, the aqueous phase was extracted with ethyl acetate, the organic phase washed with brine and dried over sodium sulfate. Over night the desired product precipitated and subsequently the crystals were collected and dried under vacuum. [2-((R)-Indan-1-ylamino)-quinolin-6-yl]-urea was obtained as a white solid (44 mg; 38%); MS: m/e=319.3 (M+H+).

1. extractionthe aqueous phase was extracted with ethyl acetate
2. washthe organic phase washed with brine
3. dry with materialdried over sodium sulfate
4. customOver night the desired product precipitated
5. customsubsequently the crystals were collected
6. customdried under vacuum