Triphosgene → 1-[2-((R)-Indan-1-ylamino)-quinolin-6-yl]-3-(1-methyl-piperidin-4-yl)-urea

HRID 1928723Notes

Reaction equation

HRID 1928723 reaction equation
[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[CH3:13][N:14]1[CH2:19][CH2:18][CH:17]([NH2:20])[CH2:16][CH2:15]1.[C@H:21]1([NH:30][C:31]2[CH:40]=[CH:39][C:38]3[C:33](=[CH:34][CH:35]=[C:36]([NH2:41])[CH:37]=3)[N:32]=2)[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22]1>>[C@H:21]1([NH:30][C:31]2[CH:40]=[CH:39][C:38]3[C:33](=[CH:34][CH:35]=[C:36]([NH:41][C:1]([NH:20][CH:17]4[CH2:18][CH2:19][N:14]([CH3:13])[CH2:15][CH2:16]4)=[O:12])[CH:37]=3)[N:32]=2)[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22]1

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 27375314-Amino-1-methylpiperidineHCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 442174691-[2-((R)-Indan-1-ylamino)-quinolin-6-yl]-3-(1-methyl-piperidin-4-yl)-urea

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 1-methyl-piperidin-4-ylamine and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=415.5 (M+H+).

Sources & evidence

ORD record
ord-cd54fefcfdf143dfbc4890338b540225
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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