Morpholine → HCID 44217309, compound

HRID 1928725Notes

Reaction equation

[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.[C@H:19]1([NH:28][C:29]2[CH:38]=[CH:37][C:36]3[C:31](=[CH:32][CH:33]=[C:34]([NH2:39])[CH:35]=3)[N:30]=2)[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:21][CH2:20]1>>[C@H:19]1([NH:28][C:29]2[CH:38]=[CH:37][C:36]3[C:31](=[CH:32][CH:33]=[C:34]([NH:39][C:1]([N:13]4[CH2:18][CH2:17][O:16][CH2:15][CH2:14]4)=[O:12])[CH:35]=3)[N:30]=2)[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:21][CH2:20]1

Participants

Reactant 3

HCID 8083Morpholine

HCID 94429Triphosgene

HCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 44217309HCID 44217309, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, morpholine and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=389.5 (M+H+).

Sources & evidence

ORD record: ord-561870835964481b9e4f2b85cf17483a
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08183380B2

Reaction notes

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