Triphosgene → HCID 44217622, compound

HRID 1928728Notes

Reaction equation

HRID 1928728 reaction equation
[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[CH2:13]([N:20]1[CH2:24][CH2:23][CH:22]([NH2:25])[CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[C@H:26]1([NH:35][C:36]2[CH:45]=[CH:44][C:43]3[C:38](=[CH:39][CH:40]=[C:41]([NH2:46])[CH:42]=3)[N:37]=2)[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:28][CH2:27]1>>[CH2:13]([N:20]1[CH2:24][CH2:23][CH:22]([NH:25][C:1]([NH:46][C:41]2[CH:42]=[C:43]3[C:38](=[CH:39][CH:40]=2)[N:37]=[C:36]([NH:35][C@H:26]2[C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH2:28][CH2:27]2)[CH:45]=[CH:44]3)=[O:12])[CH2:21]1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 27566131-Benzyl-3-aminopyrrolidineHCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 44217622HCID 44217622, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, rac-1-benzyl-3-aminopyrrolidine and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=478.6 (M+H+).

Sources & evidence

ORD record
ord-c2974b12448345a990469b991843dfda
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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