Triphosgene → HCID 44218103, compound

HRID 1928732Notes

Reaction equation

HRID 1928732 reaction equation
[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[CH2:13]([C:15]1([CH2:20][CH2:21][NH2:22])[CH2:19][CH2:18][O:17][CH2:16]1)[CH3:14].[C@H:23]1([NH:32][C:33]2[CH:42]=[CH:41][C:40]3[C:35](=[CH:36][CH:37]=[C:38]([NH2:43])[CH:39]=3)[N:34]=2)[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:25][CH2:24]1>>[C@H:23]1([NH:32][C:33]2[CH:42]=[CH:41][C:40]3[C:35](=[CH:36][CH:37]=[C:38]([NH:43][C:1]([N:22]4[CH2:14][CH2:13][C:15]5([CH2:16][O:17][CH2:18][CH2:19]5)[CH2:20][CH2:21]4)=[O:12])[CH:39]=3)[N:34]=2)[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:25][CH2:24]1

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamineHCID 68633837HCID 68633837, compound

Product 1

HCID 44218103HCID 44218103, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 2-(3-ethyl-tetrahydro-furan-3-yl)-ethylamine and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=443.7 (M+H+).

Sources & evidence

ORD record
ord-4a388027442148a880255916b3ba0260
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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